Basic Information
  • name:XU Xu
  • title:Professor
  • E-mail:xuxu@szu.edu.cn
  Personal profile
Background: 2017-Present Professor, Shenzhen University, PRC 2019-2020 Visiting Scholar, Department of Food Science, University of Massachusetts Amherst, USA 2010-2017 Associate Professor, Shenzhen University, PRC 2008-2010 Lecturer, Shenzhen University, PRC 2007-2008 Post-doctoral Research Associate, University of Bern, Switzerland 2003-2006 Ph.D., Kyushu University, Japan 2001-2002 Exchange student in Food Biophysics, Nagasaki University, Japan 2000-2003 Master in Medical Science, Ocean University of China, PRC 1996-2000 Bachelor in Medical Science, Ocean University of China, PRC Research Interests: Prof. Xu is mainly engaged in the exploration of identifying health-promoting food components, elucidating their molecular mechanisms, and enhancing their health benefits and chemical stability through novel food carrier embedding in order to develop food-based strategies for health and wellness in humans.
  Selected Publications

1. Yao L, Yang P, Luo W, Li S, Wu Y, Cai N, Bi D, Li H, Han Q, Xu X*. Macrophage-stimulating activity of European eel (Anguilla anguilla) peptides in RAW264.7 cells mediated via NF-κB and MAPK signaling pathways. Food & Function 2020, 11(12), 10968-10978.

2. Bi D, Yao L, Lin Z, Chi L, Li Hui, Xu H, Du X, Liu Q, Hu Z, Lu J, Xu X*. Unsaturated mannuronate oligosaccharide ameliorates β-amyloid pathology through autophagy in Alzheimer’s disease cell models. Carbohydrate Polymers 2021, 251: 117124.

3. Cai N, Luo W, Yao L, Li X, Wang Z, Xu H, Li H, Hu Z, Bao W, Xu X*. Activation of murine RAW264.7 macrophages by oligopeptides from sea cucumber (Apostichopus japonicus) and its molecular mechanisms. Journal of Functional Foods 2020, 75: 104229.

4. Yu B, Bi D, Yao L, Li T, Gu L, Xu H, Li X, Li H, Hu Z, Xu X*. The inhibitory activity of alginate against allergic reactions in an ovalbumin-induced mouse model. Food & Function 2020, 11(3): 2704-2713.

5. Bi D, Li X, Li T, Li X, Lin Z, Yao L, Li H, Xu H, Hu Z, Zhang Z, Liu Q, Xu X*. Characterization and neuroprotection potential of seleno-polymannuronate. Frontiers in Pharmacology 2020, 11: 21.

6. Cai N, Chen J, Bi D, Gu L, Yao L, Li X, Li H, Xu H, Hu Z, Liu Q, Xu X*. Specific degradation of endogenous Tau protein and inhibition of Tau fibrillation by tanshinone IIA through the ubiquitin-proteasome pathway. Journal of Agricultural and Food Chemistry 2020, 68(7): 2054-2062.

7. Gu L, Cai N, Lyu Y, Yao L, Wang F, Xu H, Hu Z, Li H, Xu X*. γMangostin ameliorates free fatty acid-induced lipid accumulation via the SIRT1/LKB1/AMPK pathway in HepG2 and L02 cells. Journal of Agricultural and Food Chemistry 2019, 67(50): 13929-13938.

8. Bi D, Lai Q, Liao X, Cai N, Li T, Fang W, Han Q, Yu B, Lin L, Xu H, Hu Z, Xu X*. Neuroimmunoregulatory potential of seleno-polymannuronate derived from alginate in lipopolysaccharide-stimulated BV2 microglia. Food Hydrocolloids 2019, 87: 925-932.

9. Bi D, Lai Q, Han Q, Cai N, He H, Fang W, Yi J, Li X, Xu H, Li X, Hu Z, Liu Q, Xu X*. Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation. Journal of Functional Foods 2018, 51: 113-120.

10. Bi D, Yu B, Han Q, Lu J, White W, Lai Q, Cai N, Luo W, Gu L, Li S, Xu H, Hu Z, Nie S, Xu X*. Immune activation of RAW264.7 macrophages by low molecular weight fucoidan extracted from New Zealand Undaria pinnatifida. Journal of Agricultural and Food Chemistry 2018, 66(41): 10721-10728.

11. Bi D, Lai Q, Cai N, Li T, Zhang Y, Han Q, Peng Y, Xu H, Lu J, Bao W, Liu Q, Xu X*. Elucidation of the molecular-mechanisms and in vivo evaluation of the anti-inflammatory effect of alginate-derived seleno-polymannuronate. Journal of Agricultural and Food Chemistry 2018, 66(9): 2083-2091.

12. Bi D, Zhou R, Cai N, Lai Q, Han Q, Jiang Z, Tang Z, Peng Y, Lu J, Bao W, Xu H, Xu X*. Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages. International Journal of Biological Macromolecules 2017, 105(2): 1446-1454.

13. Fang W, Bi D, Zheng R, Cai N, Xu H, Zhou R, Lu J, Wan M, Xu X*. Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages. Scientific Reports 2017, 7(1): 1663.

14. Xu X, Bi D, Wan M. Characterization and immunological evaluation of low-molecular-weight alginate derivatives. Current Topics in Medicinal Chemistry 2016, 16(8): 874-887.

15. Zhou R, Shi X, Bi D, Fang W, Wei G, Xu X*. Alginate-derived oligosaccharide inhibits neuroinflammation and promotes microglial phagocytosis of β-amyloid. Marine Drugs 2015, 13(9): 5828-5846.

16. Xu X, Bi D, Li C, Fang W, Zhou R, Li S, Chi L, Wan M, Shen L. Morphological and proteomic analyses reveal that unsaturated guluronate oligosaccharide modulates multiple functional pathways in murine macrophage RAW264.7 cells. Marine Drugs 2015, 13(4): 1798-1818.

17. Zhou R, Shi X, Gao Y, Cai N, Jiang Z, Xu X*. Anti-inflammatory activity of guluronate oligosaccharides obtained by oxidative degradation from alginate in lipopolysaccharide-activated murine macrophage RAW 264.7 cells. Journal of Agricultural and Food Chemistry 2015, 63(1): 160-168.

18. Xu X, Bi D, Wu X, Wang Q, Wei G, Chi L, Jiang Z, Oda T, Wan M. Unsaturated guluronate oligosaccharide enhances the antibacterial activities of macrophages. The FASEB Journal 2014, 28(6): 2645-2654.

19. Xu X, Wu X, Wang Q, Cai N, Zhang H, Jiang Z, Wan M, Oda T. Immunomodulatory effects of alginate oligosaccharides on murine macrophage RAW264.7 cells and their structure-activity relationships. Journal of Agricultural and Food Chemistry 2014, 62(14): 3168-3176.


职称 Professor 邮箱 xuxu@szu.edu.cn
个人简介 Background:
2017-Present Professor, Shenzhen University, PRC
2019-2020 Visiting Scholar, Department of Food Science, University of Massachusetts Amherst, USA
2010-2017 Associate Professor, Shenzhen University, PRC
2008-2010 Lecturer, Shenzhen University, PRC
2007-2008 Post-doctoral Research Associate, University of Bern, Switzerland
2003-2006 Ph.D., Kyushu University, Japan
2001-2002 Exchange student in Food Biophysics, Nagasaki University, Japan
2000-2003 Master in Medical Science, Ocean University of China, PRC
1996-2000 Bachelor in Medical Science, Ocean University of China, PRC
Research Interests:
Prof. Xu is mainly engaged in the exploration of identifying health-promoting food components, elucidating their molecular mechanisms, and enhancing their health benefits and chemical stability through novel food carrier embedding in order to develop food-based strategies for health and wellness in humans.